Drug Metabolism and Pharmacokinetics

The Drug Metabolism and Pharmacokinetics (DMPK) team resides within the VCNDD and recruits researchers over a range of disciplines to form an integrated approach and knowledge base to solving critical ADME issues in the drug discovery process and during drug candidate selection. Our researchers support backgrounds in analytical chemistry, medicinal chemistry, pharmacology, biochemistry, and behavioral sciences and come from the both academic and industrial settings. This integrated DMPK approach is unique to the VCNDD and fosters individual growth while emphasizing the key nature of a collaborative research environment.

Our mission is to support all phases of the drug discovery process within in the VCNDD and lead project teams in the areas of drug metabolism and bioactivation, absorption and distribution, mechanisms of clearance, and projected human dosing to reach maximal efficacy on target while minimizing potential drug-drug interaction liabilities.