Medicinal Chemistry

Objective

Development of small molecule in vitro probes, in vivo tool compounds and IND-ready preclinical candidates through high-throughput, iterative medicinal chemistry 

Technology 

• Matrix/Parallel library synthesis 

• Modern Synthetic Technologies: Microwave (Biotage), Photo-redox and Electrochemical synthesis 

• High-throughput Purification Technologies: (Waters LCMS, Gilson HPLC, Biotage, Teledyne Isco) 

• Supercritical Fluid Chromatography (SFC) for chiral HPLC (analytical and preparative) 

Innovation 

• Specially curated chemical building block collection for neuroscience targets 

• Real-time incorporation of in vitro and in vivo DMPK data into SAR  

• Development of intellectual property (IP) in parallel with tools for academic discovery